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A peripheral neuropathy caused by diabetes It is typical for microvascular disorders of the eyes, kidneys, and peripheral nerves to develop resulting from both type 1 and type 2 diabetes persistent hyperglycemia (45)

Recently, we have shown that purine metabolites were also linked to neurological and cognitive symptoms in the FENNS patients (Yao et al., 2012)

Most of the mutations are leaky so that many patients have residual enzyme activity

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